GlycoSeLect
The products at GlycoSeLect, Recombinant Protein Lectins, exhibit high affinity for a range of glycan epitopes displaying terminal galactose and mannose including high mannose structures, among others. RPL’s affinity for the sugars, such as Sialic Acid & Galactose, allow the proteins to be identified and targeted and therefore play an important role in Glycoprotein Profiling, besides having applications in the Biopharmaceutical, diagnostics, research, cosmetics, and food industry.
Since, the RPL products exhibit high affinity for a range of glycan epitopes, they have a wide variety of applications and are far better than their Eukaryotic counterparts as they have: –
- Greater affinity and selectivity for glycosylated targets than their Plant or Eukaryotic Lectin Counterparts.
- Products are consistently high in quality, purity, and performance whereas the Plant lectin counterparts suffer from batch-batch variations.
- Have high scalability and purification.
Among the products available at GlycoSeLect are RPL-Man2 which competes against the Plant Lectin GNL, NPL. The Glycoprotein Standard for RPL-Man2 is Glucose Oxidase. Glucose Oxidase is widely used for the determination of free glucose in body fluids and thus provides application in the medical testing industry besides having application in vegetal raw material and in the food industry. It also has many applications in biotechnology typically enzyme assays for biochemistry including biosensors in Nanotechnology.
Other products are RPL-Sia1 and RPL-Gal 1, which are competing against the Plant lectins Mal II and ECL respectively, with Fetuin and Asialofetuin as the Glycoprotein Standards. Fetuin is a glycoprotein containing sialylated N-linked and O-linked glycans that can be used as a positive control for endoglycosidase enzymes that cleave both N-linked and O-linked carbohydrates. It has a wide variety of application in the biotech industry and can undergo convenient downstream analysis by SDS-PAGE gel shift and/or mass spectrometry.
Asialofetuin provides a very efficient route for gene therapy as it strongly enhances delivery and endocytosis by cells displaying the Asialofetuin (AF) receptor, notably hepatocytes on account of incorporation of asialofetuin in liposomes. It also displays several Biochemical and physiological actions as it exhibits affinity to Asialoglycoprotein receptor (ASGP-R) on hepatocytes and uses the receptor to enter the cell. This property allows Asialofetuin to be used as a ligand to deliver drugs to hepatocytes and as a competitive inhibitor to ASGP-R.
Besides, these the other products available are RPL-αMan, RPL-Sia2, RPL-Gal 2, RPL-Sia3 among others.
